Peste Des Petits Ruminants Screening and Diagnostic Tests in African Wildlife in the Context of Rinderpest Eradication (1994–2007)
2023
Grosbois, Vladimir | Kwiatek, Olivier | Gaidet, Nicolas | Chardonnet, Philippe | Chardonnet, Bertrand | Bataille, Arnaud | Parida, Satya | Roger, François | Kock, Richard | Libeau, Geneviève | Caron, Alexandre | Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Département Systèmes Biologiques (Cirad-BIOS) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Savoirs, ENvironnement et Sociétés (SENS) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut de Recherche pour le Développement (IRD) | Département Environnements et Sociétés (Cirad-ES) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Food and Agriculture Organization of the United Nations [Rome, Italie] (FAO) | Direction Générale Déléguée à la Recherche et à la Stratégie (Cirad-Dgdrs) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Royal Veterinary College [London] ; University of London [London] | Université Eduardo Mondlane = Eduardo Mondlane University = Universidade Eduardo Mondlane (UEM) | This retrospective study was supported by a grant from the European Commission Animal Health and Welfare European Research Area Network for the IUEPPR Project "Improved Understanding of Epidemiology of PPR" in the framework of ANIHWA 2013 and by a grant (SI2.756606) from the European Commission Directorate General for Health and Food Safety awarded to the European Union Reference Laboratory for Peste des petits ruminants (EURL-PPR). The study relies on extensive collaborations and contributions from multiple collaborators across countries, from field assistants to protected areas and veterinary services managers in the context of the African Wildlife Veterinary Program within the PARC and PACE programs. Open-access funding was enabled and organized by COUPERIN CY23.
International audience
Mostrar más [+] Menos [-]Inglés. Peste des petits ruminants (PPR) virus causes a major disease in domestic and wild small ruminants. Understanding the role of wildlife in PPR virus ecology is important for PPR control and its eradication targeted worldwide in 2030. Developing diagnostic tools that provide reliable data for PPR detection in wildlife will help monitor wild populations for PPR and support the eradication program. We analyze a continental-scale dataset from African free-ranging wild ungulates (n = 2570) collected between 1994 and 2007. A Bayesian model estimated the performance of ELISA tests against PPR and rinderpest and their prevalence in African bufalo. Te Hand N-ELISA tests used, not initially developed for wildlife, showed poor sensitivities for the detection of PPR antibodies in African bufalo. Te estimations of PPR antibody prevalence derived from the results of these tests for animals presumably not exposed or potentially exposed to PPR were uncertain. Tus, poor performances of these PPR serological tests in wildlife would not allow robust estimations of PPR antibody prevalence in African bufalo and would be extremely speculative in non-bufalo wild ungulate species. We recommend that current and new tests be validated for wildlife hosts to provide sufcient sensitivity and specifcity of detection and a diagnostic protocol be developed for PPR wildlife research.
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