Wheat ATIs: Characteristics and Role in Human Disease
2021
Geisslitz, Sabrina | Shewry, Peter | Brouns, Fred | America, Antoine | Caio, Giacomo Pietro Ismaele | Daly, Matthew | d'Amico, Stefano | de Giorgio, Roberto | Gilissen, Luud | Grausgruber, Heinrich | Huang, Xin | Jonkers, Daisy | Keszthelyi, Daniel | Larré, Colette | Masci, Stefania | Mills, Clare | Møller, Marie Sofie | Sorrells, Mark | Svensson, Birte | Zevallos, Victor | Weegels, Peter Louis | Karlsruhe Institute of Technology = Karlsruher Institut für Technologie (KIT) | Rothamsted Research ; Biotechnology and Biological Sciences Research Council (BBSRC) | Fac Hlth Med & Life Sci, Dept Human Biol, Nutr & Toxicol Res Inst Maastricht NUTRIM ; Maastricht University [Maastricht] | Wageningen University and Research [Wageningen] (WUR) | Università degli Studi di Ferrara = University of Ferrara (UniFE) | IHU-LIRYC ; Université Bordeaux Segalen - Bordeaux 2-Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux) | Austrian Agency for Health and Food Safety (AGES) | Department of internal medicine and gastroenterology ; Alma Mater Studiorum Università di Bologna = University of Bologna (UNIBO)-centro unificato di ricerca biomedica apllicata-St Orsola Hospital | Universität Wien = University of Vienna | Helsingin yliopisto = Helsingfors universitet = University of Helsinki | Maastricht University [Maastricht] | Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA) ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Università degli studi della Tuscia = Tuscia University [Viterbo] (UNITUS) | University of Manchester [Manchester] | Danmarks Tekniske Universitet = Technical University of Denmark (DTU) | Cornell University [New York] | Northumbria University [Newcastle] | Nutrition Committee of the Rank Prize Funds; StichtingWetenschappelijk Onderzoek Limburg (SWOL); UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) : BB/P016855/1.
International audience
Mostrar más [+] Menos [-]Inglés. Amylase/trypsin-inhibitors (ATIs) comprise about 2–4% of the total wheat grain proteins and may contribute to natural defense against pests and pathogens. However, they are currently among the most widely studied wheat components because of their proposed role in adverse reactions to wheat consumption in humans. ATIs have long been known to contribute to IgE-mediated allergy (notably Bakers' asthma), but interest has increased since 2012 when they were shown to be able to trigger the innate immune system, with attention focused on their role in coeliac disease which affects about 1% of the population and, more recently, in non-coeliac wheat sensitivity which may affect up to 10% of the population. This has led to studies of their structure, inhibitory properties, genetics, control of expression, behavior during processing, effects on human adverse reactions to wheat and, most recently, strategies to modify their expression in the plant using gene editing. We therefore present an integrated account of this range of research, identifying inconsistencies, and gaps in our knowledge and identifying future research needs. Note This paper is the outcome of an invited international ATI expert meeting held in Amsterdam, February 3-5 2020
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Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique