A genomic map of climate adaptation in Mediterranean cattle breeds
2019
Flori, Laurence | Moazami-Goudarzi, Katayoun | Alary, Véronique | Araba, Abdelillah | Boujenane, Ismaïl | Boushaba, Nadjet | Casabianca, François | Casu, Sara | Ciampolini, Roberta | Coeur d'Acier, Armelle | Coquelle, Corinne | Delgado, Juan-Vicente | El-Beltagi, Ahmed | Hadjipavlou, Georgia | Jousselin, Emmanuelle | Landi, Vincenzo | Lauvie, Anne | Lecomte, Philippe | Ligda, Christina | Marinthe, Caroline | Martínez, Amparo | Mastrangelo, Salvatore | Menni, Dalal | Moulin, Charles-Henri | Osman, Mona-Abdelzaher | Pineau, Olivier | Portolano, Baldassare | Rodellar, Clementina | Saïdi-Mehtar, Nadhira | Sechi, Tiziana | Sempere, Guilhem | Thevenon, Sophie | Tsiokos, Dimitrios | Laloë, Denis | Gautier, Mathieu | Systèmes d'élevage méditerranéens et tropicaux (UMR SELMET) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro) | Génétique Animale et Biologie Intégrative (GABI) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Institut Agronomique et Vétérinaire Hassan II (IAV Hassan II) | Université des sciences et de la Technologie d'Oran Mohamed Boudiaf [Oran] (USTO MB) | Laboratoire de Recherches sur le Développement de l'Elevage (LRDE) ; Institut National de la Recherche Agronomique (INRA) | Agricultural Research Agency of Sardegna ; Partenaires INRAE | Dipartimento di Scienze Veterinarie | Centre de Biologie pour la Gestion des Populations (UMR CBGP) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [Occitanie])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro) | Corsica Vaccaghji ; Partenaires INRAE | Universidad de Córdoba = University of Córdoba [Córdoba] | Animal Production Research Institute (APRI) | Agricultural Research Institute | Laboratorio de Genetica Molecular Aplicada ; Partenaires INRAE | Hellenic Agricultural Organization Demeter (HAO Demeter) | Università degli studi di Palermo - University of Palermo (UNIPA) | Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro) | Centre de recherche de la Tour du Valat (CRTV) | Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse | Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides (UMR INTERTRYP) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Université de Bordeaux (UB) | Computational Biology Institute (IBC) | INRA Metaprogramme ACCAF grant 2012 (GALIMED project) ; Animal Genetics Division of INRA
International audience
Mostrar más [+] Menos [-]Inglés. Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short term evolutionary response to climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome-wide association analyses with covariables discriminating the different Mediterranean climate sub-types. This provided insights into both the demographic and adaptive histories of Mediterranean cattle. In particular, a detailed functional annotation of genes surrounding variants associated with climate variations highlighted several biological functions involved in Mediterranean climate adaptation such as thermotolerance, UV protection, pathogen resistance or metabolism with strong candidate genes identified (e.g. NDUFB3, FBN1, METTL3, LEF1, ANTXR2 and TCF7). Accordingly, our results suggest that main selective pressures affecting cattle in Mediterranean area may have been related to variation in heat and UV exposure, in food resources availability and in exposure to pathogens, such as anthrax bacteria (Bacillus anthracis). Furthermore, the observed contribution of the three main bovine ancestries (indicine, European and African taurine) in these different populations suggested that adaptation to local climate conditions may have either relied, on standing genomic variation of taurine origin or adaptive introgression from indicine origin, depending on the local breed origins. Taken together, our results highlight the genetic uniqueness of local Mediterranean cattle breeds and strongly support conservation of these populations
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