Long‐term safety of dietary salt: A 5‐year ProspEctive rAndomized bliNded and controlled stUdy in healThy aged cats ( PEANUT study)
2024
Reynolds, Brice, S | Chetboul, Valerie | Elliott, Jonathan | Laxalde, Jeremy | Nguyen, Patrick | Testault, Isabelle | Dorso, Laetitia | Abadie, Jérôme | Lefebvre, Hervé, P | Biourge, Vincent | Innovations Thérapeutiques et Résistances (InTheRes) ; Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Unité de cardiologie d'Alfort (UCA) ; Centre hospitalier universitaire vétérinaire d'Alfort - Animaux de compagnie {EnvA] (CHUV-AC-ENVA) ; Centre Hospitalier Universitaire Vétérinaire d'Alfort [Maison-Alfort] (CHUVA-ENVA) ; École nationale vétérinaire d'Alfort (ENVA)-École nationale vétérinaire d'Alfort (ENVA)-Centre Hospitalier Universitaire Vétérinaire d'Alfort [Maison-Alfort] (CHUVA-ENVA) ; École nationale vétérinaire d'Alfort (ENVA)-École nationale vétérinaire d'Alfort (ENVA) | Institut Mondor de Recherche Biomédicale (IMRB) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) | Royal Veterinary College [London] ; University of London [London] | Royal Canin Research Center ; Royal Canin | École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS) | Centre Hospitalier Vétérinaire Atlantia ; Centre Hospitalier Vétérinaire Atlantia [Nantes, France] | Centre Hospitalier Universitaire Vétérinaire d'Oniris [Nantes] (CHUV) ; École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS) | Fédération des laboratoires d'analyses vétérinaires d'Oniris (LabOniris) ; École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS) | Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)
International audience
Mostrar más [+] Menos [-]Inglés. Abstract Background High‐salt diets promote urine dilution and decrease urolithiasis risk. Objective Prospectively evaluate the safety of chronic high dietary salt intake (randomized controlled trial). Animals Twenty research colony neutered, healthy aged cats (11.5 years [10.0‐11.6], median [interquartile range]). Methods Healthy cats were randomized to control or high‐salt dry diets (sodium: 1.02 ± 0.16 [mean, SD] and 3.26 ± 0.30 g/Mcal metabolizable energy [ME], respectively; chloride: 2.26 ± 0.33 and 5.71 ± 0.28 g/Mcal ME, respectively), fed for up to 60 months. Assessments included CBC, plasma biochemistry, urinalysis, glomerular filtration rate (GFR), blood pressure, renal and cardiac (conventional Doppler and 2‐dimensional color tissue Doppler) imaging, annually. Cats that died or were euthanized underwent necropsy. Diet effects over time were evaluated with linear mixed models. Results Follow‐up duration (median [Interquartile range]) was similar between the control (38.7 months [28.6‐48.2]) and high‐salt group (51.4 months [45.7‐59.0]). Diet had no significant effect on changes in GFR, blood pressure, plasma creatinine concentration, end‐diastolic left ventricular (LV) wall thicknesses, LV internal diameters, LV systolic function, left atrial size, or systolic and diastolic Doppler variables. One control cat developed hypertension. One high‐salt group cat developed persistent azotemia. Serial plasma biochemistry and urine specific gravity suggested early chronic kidney disease in 4 nonazotemic cats (2 per group), consistent with necropsy findings. Conclusions and Clinical Importance In healthy aged cats, a commercial veterinary diet containing 3.26 ± 0.30 g/Mcal ME sodium was safe with regard to renal and cardiac function for up to 5 years.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique