INFLUENCE OF COUMARIN ON PRODUCTIVITY, IMMUNITY AND ANTIOXIDANT STATUS OF HEALTHY BROILERS

Background. Coumarins are natural compounds (secondary metabolites of plant origin) that have a wide range of biological activity, mainly due to their ability to interact with various enzymes and receptors in living organisms. The relevance of their use in feeding poultry is obvious, in view of the active search for alternatives to feed antibiotics. The aim of the study was to evaluate the effect of coumarin on the productivity and antioxidant status of broiler chickens. Materials and methods. Objects of study: broiler chickens of the Arbor Acres cross, 7-hydroxycoumarin. The experiment was carried out on 180 heads of 7-day-old broiler chickens (n=45). Control - the main diet (OR), 1 experimental – OR + coumarin (at a dose of 1 mg/kg of feed/day, 2 experimental – OR + coumarin at a dose of 2 mg/kg of feed / day, 3 experimental – OR + coumarin in at a dose of 3 mg/kg feed/day. Hematological parameters (number and type of leukocytes) were taken into account on an automatic hematological analyzer URIT-2900 Vet Plus (URIT Medical Electronic Group Co., Ltd, China). Biochemical analysis of blood serum was performed on an automatic biochemical analyzer CS-T240 (Dirui Industrial Co., Ltd, China). Results. The inclusion of 7-hydroxycoumarin in the diet contributed to an increase in live weight in the experimental groups by 8,6–19,4%; (by 9,2–21,1%), slaughter yield (up to 4,76%), against the background of a decrease in feed consumption per 1 kg of live weight gain (by 3,5–15,7%). showed a decrease in total protein, albumin, ALT (groups 1 and 2 (p≤0,05)), bilirubin (by 38,3–68,6%), cholesterol (in group 3 by 16,4% (p≤0,05)), triglycerides (groups 1 and 2, p≤0,05), urea (41,8–65,1%; p≤0,05), against the background of elevated iron levels (groups 1 and 2, p≤0,05). Depending on the dose of 7-hydroxycoumarin, a decrease in the number of leukocytes (group 1, p≤0,05), neutrophils (groups 1 and 2, p≤0,05), monocytes, eosinophils and basophils (p≤ 0,05). Antioxidant indicators were characterized by a decrease in the level of malondialdehyde (by 63,7–77,3%), superoxide dismutase activity (22,4–71,5%) and an increase in catalase activity (by 24,3–46,1%). Conclusion. Thus, the inclusion of 7-hydroxycoumarin (2 mg/kg feed/day) in the diet contributed to an increase in the live weight of broiler chickens, feed intake, slaughter yield, against the background of a lower feed consumption per 1 kg of live weight gain; had a positive effect on the parameters of the liver (ALT, total bilirubin), lipid and nitrogen metabolism (triglycerides, urea), the antioxidant status of the body of broiler chickens.