CHANGES IN VARIOUS HEMATO-BIOCHEMICAL PARAMETERS AFTER PARTIAL AND COMPLETE NEPHRECTOMY IN RABBITS

Some variations occur in hemato-biochemical parameters after surgical removal of a complete or a portion of kidney. There is very less data available on changes in hemato-biochemical profile in early post-operative days after partial or complete nephrectomy in rabbits. The current research study was designed to evaluate the effects of partial and complete nephrectomy on various hemato-biochemical parameters in rabbits in early post-operative days. We used twelve clinically healthy rabbits of either sex, age ranging between six months and one year, weight between 1.5 kg and 2 kg. Rabbits were divided into two groups named as group A and Group B. Group A underwent with partial nephrectomy and group B with complete nephrectomy. Blood samples were taken from jugular vein for hematology and biochemistry at day 0, 3rd and day 6thof surgery. General linear model with repeated measures design was applied to evaluate and compare the effects within groups as well as between groups. All mean values at day 3rd and 6th, were compared with baseline values which showed a significant difference of various hemato-biochemical parameters at day 3rd and 6th within groups. However, anon-significant difference in various hemato-biochemical parameters was found between both partial and complete nephrectomised groups with some inconsiderable alterations. It is concluded that partial and complete nephrectomy causes mild changes on hemato-biochemical parameters in early post-operative days. Partial nephrectomy causes post-operative complications including kidney inflammation, congestion of abdominal cavity and death. Further study on larger sample size will be helpful for patients who require long term monitoring.