The functions and mechanisms of prefoldin complex and prefoldin-subunits
2020
Jiaxin Liang | Longzheng Xia | Linda Oyang | Jinguan Lin | Shiming Tan | Pin Yi | Yaqian Han | Xia Luo | Hui Wang | Lu Tang | Qing Pan | Yutong Tian | Shan Rao | Min Su | Yingrui Shi | Deliang Cao | Yujuan Zhou | Qianjin Liao
Abstract The correct folding is a key process for a protein to acquire its functional structure and conformation. Prefoldin is a well-known chaperone protein that regulates the correct folding of proteins. Prefoldin plays a crucial role in the pathogenesis of common neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease). The important role of prefoldin in emerging fields (such as nanoparticles, biomaterials) and tumors has attracted widespread attention. Also, each of the prefoldin subunits has different and independent functions from the prefoldin complex. It has abnormal expression in different tumors and plays an important role in tumorigenesis and development, especially c-Myc binding protein MM-1. MM-1 can inhibit the activity of c-Myc through various mechanisms to regulate tumor growth. Therefore, an in-depth analysis of the complex functions of prefoldin and their subunits is helpful to understand the mechanisms of protein misfolding and the pathogenesis of diseases caused by misfolded aggregation.
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