The efficacy of combined micronized Niclosamideand Albendazole-based dosage forms against bothriocephalosis of cyprinids
2023
T. A. Vasilyeva | D. P. Skachkov
The purpose of the research is to develop and test new combined dosage forms against bothriocephalosis of cyprinids in the cage culture fishery.Materials and methods. Combined micronized Niclosamide- and Albendazole-based dosage forms were developed; labscale batches of dosage forms of drugs and medicated feeds were developed with these drug forms; Bothriocephalus sp. infection rate in fish was determined during the growing period; and preliminary test effectiveness was confirmed for combined micronized niclosamide- and albendazole-based dosage forms against bothriocephalosis in cyprinids in the incubation shop of a cage culture fishery according to standard practices. The efficacy was assessed for combined micronized niclosamide- and albendazole-based dosage forms.Results and discussion. The preliminary tests of combined micronized Albendazole- and Niclosamide-based dosage forms as part of medicated feeds showed 100% extense-effectiveness with 100% intense-effectiveness, and 60% extenseeffectiveness with 77.8% intense-effectiveness when administered once at a dose of 5% of the fish weight (doses for the active substance of 50 and 40 mg/kg, respectively).
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