A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection
2022
Pasquale Laise | Megan L. Stanifer | Gideon Bosker | Xiaoyun Sun | Sergio Triana | Patricio Doldan | Federico La Manna | Marta De Menna | Ronald B. Realubit | Sergey Pampou | Charles Karan | Theodore Alexandrov | Marianna Kruithof-de Julio | Andrea Califano | Steeve Boulant | Mariano J. Alvarez
Master Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model.
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