The oncological relevance of fragile sites in cancer
2021
Benjamin S. Simpson | Hayley Pye | Hayley C. Whitaker
In this Perspective, Simpson, Pye, and Whitaker discuss recent research identifying structural genomic variants in human cancers with a particular focus on deletions and duplications at genomic fragile sites. They argue that tumours with predominantly fragile site structural variants represent a distinct mutational signature that warrants further research.
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