Shaping the CD4+ memory immune response against tuberculosis: the role of antigen persistence, location and multi-functionality
2012
Ancelet Lindsay | Kirman Joanna
Effective vaccination against intracellular pathogens, such as tuberculosis (TB), relies on the generation and maintenance of CD4 memory T cells. An incomplete understanding of the memory immune response has hindered the rational design of a new, more effective TB vaccine. This review discusses how the persistence of antigen, the location of memory cells, and their multifunctional ability shape the CD4 memory T cell response against TB.
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