Anti-inflammatory potential of different extracts isolated from the roots of Ficus lacor buch. Hum and Murraya koenigii L. spreng
2014
Sindhu Rakesh K. | Arora Sandeep
The present study was undertaken to evaluate the anti-inflammatory potential of Murraya koenigii root extracts petroleum ether, ethyl acetate and chloroform (MKPE, MKEA and MKCF, respectively) and Ficus lacor aerial root extracts petroleum ether, ethyl acetate, chloroform and ethanol (FLPE , FLET, FLCF and FLET, respectively) at doses of 50 and 100 mg/kg body weight (b.w.) using animal models of acute inflammation (carrageenan-, histamine- and serotonin-induced inflammation). The results of the Murraya koenigii roots chloroform extract caused 66.4% inhibition and the ethanol extract of Ficus lacor aerial roots caused 68.3% inhibition at the dose of 50 mg/kg b.w. At a higher dose of 100 mg/kg b.w., MKPE and MKCF showed 55.10% and 70.10% inhibition, respectively. FLPE and FLET showed 74.50% and 75.40% inhibition, respectively, in the carrageenan-induced inflammation model. In histamine-induced inflammation, the MKCF showed 60% inhibition, and 67.01% and 68.02% inhibition with the petroleum ether and ethanol extracts, respectively, in Ficus lacor aerial roots at the dose of 50 mg/kg b.w. At a higher dose (100 mg/kg b.w.), MKCF showed 64% inhibition. FLPE and FLET showed 70.13%and 74.01% inhibition, respectively; 62.15% and 66.10% inhibition was observed with the petroleum ether and ethanol extracts of Ficus lacor aerial roots at 50 mg/kg b.w. At higher dose (100 mg/kg b.w.), FLPE and FLET showed 69.10% and 68.72% inhibition in serotonin-induced inflammation.
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