Immune Modulatory Effects of Probiotic <i>Streptococcus thermophilus</i> on Human Monocytes
2021
Narges Dargahi | Joshua C. Johnson | Vasso Apostolopoulos
Ingesting probiotics contributes to the development of a healthy microflora in the GIT with established benefits to human health. Some of these beneficial effects may be through the modulation of the immune system. In addition, probiotics have become more common in the treatment of many inflammatory and immune disorders. Here, we demonstrate a range of immune modulating effects of <i>Streptococcus thermophilus</i> by human monocytes, including decreased mRNA expression of IL-1R, IL-18, IFNαR1, IFNγR1, CCL2, CCR5, TLR-1, TLR-2, TLR-4, TLR-5, TLR-6, TLR-8, CD14, CD86, CD4, ITGAM, LYZ, TYK2, IFNR1, IRAK-1, NOD2, MYD88, SLC11A1, and increased expression of IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-23, IFNγ, TNFα, CSF-2. The routine administration of <i>Streptococcus thermophilus</i> in fermented dairy products and their consumption may be beneficial to the treatment/management of inflammatory and autoimmune diseases.
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