State of the antioxidant system in Danio rerio fish due to the chlorpyrifos intoxication
2021
V. V. Dovhaniuk | V. P. Rosalovsky | Yu. T. Salyha
The article presents the results of studies of acute intoxication in Danio Rerio fish by chlorpyrifos at concentrations 0.5 mg/L; 0.75 mg/L and 1 mg/L of aquarium water for 24 h and its influence on the content of TBK-active products, catalase activity (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPO), glutathione reductase (GR) in their tissues. After 24 h in the fish staying in water with chloropyrifos added in concentrations 0.75 mg/L and 1 mg/L we have revealed an increase of the content of TBK-active products in the studied tissues compared to the control values. The linear nature of the growth of the CAT enzymatic activity in the tissues of head and torso due to the effects of chloropyrifos in doses of 0.5 mg/L; 0.75 mg/L and 1 mg/L. was shown. On the background of the catalase activity growth in Danio rerio, in 24 h after the action of the toxicant, there was an inversely proportional dependence between the dose of chlorpyrifos and the activity of GPOs in both investigated parts of the fish body. In the tissues of the head and torso, inhibition of SOD activity for the action of chlorpyrifos has been established. The activity of this enzyme was the lowest at the chlorpyrifos concentration 0.75 mg/L. The obtained results complement the data on the toxic effect of chlorpyrifos on ichthyofauna and on the course of chlorpyrifos-induced oxidative stress in Danio rerio fish. The obtained data can be used in the development of additional biochemical markers of chlorpyrifos and other phosphor organic compounds intoxication and in toxicological and environmental experiments, taking into account the growing intensity of the use of insecticidal preparations in agricultural production and everyday life.
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