Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis
2022
Takeshi Suzuki | Yoshitaka Sato | Yusuke Okuno | Fumi Goshima | Tadahisa Mikami | Miki Umeda | Takayuki Murata | Takahiro Watanabe | Koichi Watashi | Takaji Wakita | Hiroshi Kitagawa | Hiroshi Kimura
A genome-wide CRISPR screen for HSV-1 host factors using near-haploid HAP1 cells revealed PAPSS1 as an essential factor for heparan sulfate biosynthesis and HSV-1 infection, and identified several other host factors also involved in both processes.
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