Vitamin E supplementation and renal functions in acute celphos poisoning

Background: The present study was designed to evaluate the effects of vitamin E on phostoxin-induced changes in renal biochemical parameters in rats. Methods: Thirty disease free albino rats were selected to study the effect of acute aluminum phosphide poisoning (ALP poisoning) were further divided into 3 subgroups of ten each: A, B and C. Group A consists of rats given vehicle (Ginni Oil) only. Group B consists of rats given 5 ml “Celphos'mixture” (or 0.3mg/g body wt.). Group C consists of rats with acute Celphos poisoning along with Vitamin E (1.5 mg Vitamin E/g body weight of rat). Result: Mean serum creatinine concentration was significantly increased in both group B and group C as compared to group A. There is decrease in mean serum creatinine levels in acute ALP poisoning after vitamin E supplementation (group C) as compared to acute aluminium phosphide poisoning (group B), although this difference was not statistically significant. The rats were administered the doses via an infant feeding tube No. 8 and blood was obtained by Cardiac puncture one hour after feeding the dose. Serum Urea, serum creatinine and superoxide levels were estimated. The superoxide levels (nitroblue tetrazolium [NBT] reduction) were estimated. Mean serum urea concentration was significantly increased in both group B and group C as compared to group A. There is decrease in mean serum urea levels in acute ALP poisoning after vitamin E supplementation (group C) as compared to acute ALP poisoning (group B), although this difference was not statistically significant. NBT reduction was significantly increased in Group B as compared to Group A. Administration of Vitamin E to rats of Group C resulted in significant decrease of NBT reduction. Conclusion: Findings of the present study showed that Vitamin E via its antioxidant action and anti-inflamatory effects has protective effect on phosphine-induced toxicity in rats.