Oxypeucedanin: Chemotaxonomy, Isolation, and Bioactivities
2021
Javad Mottaghipisheh
The present review comprehensively gathered phytochemical, bioactivity, and pharmacokinetic reports on a linear furanocoumarin, namely oxypeucedanin. Oxypeucedanin (OP), which structurally contains an epoxide ring, has been majorly isolated from ethyl acetate-soluble partitions of several genera, particularly <i>Angelica</i>, <i>Ferulago</i>, and <i>Prangos</i> of the Apiaceae family; and <i>Citrus,</i> belonging to the Rutaceae family. The methanolic extract of <i>Angelica dahurica</i> roots has been analytically characterized as the richest natural OP source. This naturally occurring secondary metabolite has been described to possess potent antiproliferative, cytotoxic, anti-influenza, and antiallergic activities, as assessed in preclinical studies. In order to explore potential drug candidates, oxypeucedanin, its derivatives, and semi-synthetically optimized analogues can be considered for the complementary assessments of biological assays.
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