Influence of systemic fluoroquinolone administration on the presence of <it>Pasteurella multocida </it>in the upper respiratory tract of clinically healthy calves
2008
Kehrenberg Corinna | Cox Bianca | Deprez Piet | Schwarz Stefan | Croubels Siska | Catry Boudewijn | Opsomer Geert | Decostere Annemie | Haesebrouck Freddy
<p>Abstract</p> <p>The influence of enrofloxacin administration (5 mg/kg) for five consecutive days on the occurrence of <it>Pasteurella multocida </it>in the upper respiratory tract of two healthy calves was monitored over a 10-day period. From nasal swabs of two additional healthy control calves, which received a placebo saline administration, <it>P. multocida </it>was isolated throughout the study period. In the enrofloxacin treated calves, <it>P. multocida </it>was not demonstrated in the nasopharynx from 48 h after the first injection until two days after the last administration, when <it>P. multocida </it>reappeared and proved to be clonal in nature to the original isolates. During the experiment, no change in minimal inhibitory concentration for enrofloxacin of the <it>P. multocida </it>isolates was detected (MIC ≤ 0.015 μg/mL). Enrofloxacin concentrations were determined in the plasma by a high-performance liquid chromatography method with fluorescence detection. The PK/PD indices AUC/MIC and C<sub>max</sub>/MIC ratio were calculated and found to be 1157.7 and 129.8, respectively. Remarkably, the respiratory pathogen <it>Arcanobacterium pyogenes </it>became the predominant recovered organism in the nasopharynx of one animal following enrofloxacin therapy throughout the remaining of the experiment.</p>
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