Lactobacillus gasseri SBT2055 enhances oral tolerance in mice via breastfeeding
2019
Matsunaga, A. (Kyoto Women's University, Kyoto (Japan). Department of Food and Nutrition) | Matsumoto-Takagi, K. | Yamashita, M. | Mori-Kizu, K. | Hirose, J. | Kabuki, T. | Sakai, F. | Narita, H.
Maternal administration of probiotics is known to be effective for prevention of allergic symptoms in babies by suppressing the immune reaction to orally ingested proteins (oral tolerance). We investigated whether breast milk nourishment by mother mice that had been orally administrated Lactobacillus gasseri SBT2055 (LG2055) with food antigen contributed to allergy prevention in their pups. Female BALB/c mice (dams) were fed a diet containing casein (C group), egg white (E group), or egg white with LG2055 (E + LG group). After induction of pregnancy, pups fed on their dam's milk were systemically immunized with ovalbumin (OVA). Then, at the age of seven weeks, the pups were given an intragastric OVA challenge. The incidence of diarrhea was significantly suppressed in pups of the E + LG group relative to the E group. Moreover, the amounts of total IgA and OVA-specific IgA immune complex (IgA-IC) in the breast milk were significantly increased by administration of LG2055. These findings suggest that the increase of IgA-IC in breast milk by LG2055 might closely correlate with enhancement of oral tolerance in pups.
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