Comparison of gut tight junction gene expression in C57BL/6J and BALB/c mice after chronic social defeat stress
2019
Yamagishi, N. ((Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki (Japan)), (Wakayama Medical University School of Medicine, Wakayama, Wakayama (Japan). Department of Anatomy and Cell Biology)) | Omata, Y. | Aoki-Yoshida, A. | Moriya, N. | Goto, T. | Toyoda, A. | Aoki, R. | Suzuki, C. | Takayama, Y.
Chronic social defeat stress (CSDS), which subjects a male mouse to repeated social subordination by an aggressor male mouse, results in the onset of depression-like behaviors. CSDS in rodents is a useful model for studying the mechanisms that underlie anxiety and depression. We investigated the effect of CSDS on expression of tight junction (TJ) components in colon in C57BL/6J and BALB/c mice to address the correlation of CSDS and the development of inflammatory intestinal disease associated with epithelial barrier dysfunction. After 10 consecutive days of CSDS, BALB/c mice displayed highly social aversive behavior compared to C57BL/6J mice, which was accompanied by the suppression of intestinal Claudin-1 expression. These observations suggest that increased susceptibility to CSDS in BALB/c mice was caused by the downregulation of Claudin-1. The CSDS model with BALB/c mice is a potentially useful system for evaluating food components for psychological stress control.
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