Beta-nicotinamide mononucleotide, an anti-aging candidate compound, is retained in the body for longer than nicotinamide in rats
2016
Kawamura, T. (The University of Shiga Prefecture, Hikone, Shiga (Japan). School of Human Cultures, Department of Nutrition) | Mori, N. | Shibata, K.
The turnover of the oxidized form of nicotinamide adenine dinucleotide (NADsup(+)) has attracted interest in regard to longevity. Thus, compounds that can rapidly increase the cellular NADsup(+) concentration have been surveyed by many researchers. Of those, beta-nicotinamide mononucleotide (beta-NMN) has been focused on. Studies on the biosynthesis of NADsup(+) from beta-NMN have been reported at the cellular level, but not at the whole animal level. In the present study, we investigated whether beta-NMN is superior to nicotinamide (Nam) as a precursor of NADsup(+) in whole animal experiments. To this end we compared the NADsup(+) concentration in the blood and the urinary excretion amounts of NADsup(+) catabolites. Rats were intraperitoneally injected with beta-NMN or Nam. After the injection, blood samples and urine samples were collected at 3-h intervals. The concentration of blood total NAD (NADsup(+)+NADH) in each sample showed no significant differences between the two groups. The urinary excretion amounts of NADsup(+) catabolites in the urine samples collected at 3-6 h after the injection were lower in the beta-NMN group than in the Nam group. These results suggest that beta-NMN is retained in the body for longer than Nam.
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