Study on glycemic control by functional foods through regulation of pancreatic beta-cell function
2017
Harada, N. (Osaka Prefecture University, Sakai, Osaka (Japan). Graduate School of Life and Environmental Sciences)
Pancreatic beta-cells play a pivotal role in glucose metabolism through secretion of insulin in response to glucose concentration. In order to prevent type 2 diabetes mellitus, it is important to maintain the secretion of insulin from beta-cells. An attractive option to prevent the onset of type 2 diabetes is the use of food or supplements that improve beta-cell function. In this study, a bioactive food supplement was examined to determine its effect on cultured beta-cells, isolated mouse pancreatic islets, and mice. S-Equol (7-hydroxy-3-(4'-hydroxyphenyl) chroman) is produced by gut microbiota from the isoflavone daidzein, which is found in Pueraria montana (Kudzu) root or Glycine max (soybean). S-Equol enhanced the proliferation and insulin secretion of beta-cells and decreased their susceptibility to oxidative stress by activating protein A signaling in an enantioselective manner. These effects were stronger with S-equol than with daidzein. These results indicate that S-equol boosts beta-cell function, suggesting that it may help to prevent type 2 diabetes mellitus.
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