Anthocyanin cyanidin-3-glucoside attenuates platelet granule release in mice fed high-fat diets
2017
Zhou, F.H. ((Sun Yat-Sen University, Guangzhou (People's Republic of China). School of Public Health, Department of Nutrition), (Sun Yat-Sen University (People's Republic of China). Guangdong Provincial Key Laboratory of Food, Nutrition and Health)) | Deng, X.J. | Chen, Y.Q. | Ya, F.L. | Zhang, X.D. | Song, F. | Li, D. | Yang, Y.
Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-beta1 in gel-filtered platelets, in addition to attenuating serum PF4 and beta-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.
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