Bilateral rostral mandibulectomy for treatment of a rapidly-growing amyloid-producing odontogenic tumor in a shih-tzu dog
2016
Nishi, A. ((Aoba Animal Hospital, Miyazaki-shi, Miyazaki (Japan)), (Hassen-kai, Saito-shi, Miyazaki (Japan). Division of Animal Medical Research)) | Itoh, T. | Uchida, K. | Chambers, J. | Shii, H.
An 11-year-old castrated male Shih-Tzu presented with a rapidly-growing mandibular mass. A hard gingival mass of 2.7 * 1.5 cm in size was present on the rostral mandible in the vicinity of the incisors and both canines. Bone resorption was detected on radiographs. An excisional biopsy was performed at first admission and the mass was diagnosed as an amyloid-producing odontogenic tumor (APOT). The mass had grown to 3.3 * 3.0 cm in size by 14 days after first admission and was excised by bilateral rostral mandibulectomy, with an incision made between the second and third premolar teeth. Histopathology identified small nests or cords of odontogenic epithelial cells, and marked deposition of amyloid based on Congo-red staining. These findings suggest that the rapid growth of the gross lesion resulted from both cell proliferation and marked amyloid production. Complete removal of the APOT lesion was histologically indicated, and neither recurrence nor metastasis was observed for 49 months after surgery. Therefore, early wide excision, including rostral mandibulectomy, should be considered a useful treatment for locally invasive, rapidly growing APOT in dogs.
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