Ovine TRIM5α can restrict visna/maedi virus
2012
Jauregui, Paula | Crespo Otano, Helena | Glaría Ezquer, Idoia | Luján, Lluís | Contreras, A. | Rosati, Sergio | Andrés Cara, Damián de | Amorena Zabalza, Beatriz | Towers, G. J. | Reina Arias, Ramsés | IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua | Gobierno de Navarra / Nafarroako Gobernua, IIQ14064.RI1
The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections.
Mostrar más [+] Menos [-]This work was supported by grants from CICYT (no. AGL2010-22341- C04-01), the Government of Navarra (no. IIQ14064.RI1), the UK Medical Research Centre, and the UK National Institute of Health Research UCL/UCLH Comprehensive Biomedical Research Centre and fellowships from the Spanish Ministry of Science and Innovation (P.J.) and the Wellcome Trust (G.J.T.).
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