Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1-[(1 H -indol-3-ylmethyl)methylamino]-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols
2010
Guillon, Rémi | Logé, Cédric | Pagniez, Fabrice | Ferchaud-Roucher, Véronique | Duflos, Muriel | Picot, Carine | Pape, Patrice Le | Cibles et Médicaments des Infections et de l'Immunité - EA 1155 (IICiMed) ; Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques (UFR SPB) ; Université de Nantes (UN)-Université de Nantes (UN) | Physiopathologie des Adaptations Nutritionnelles (PhAN) ; Institut National de la Recherche Agronomique (INRA)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE) ; Université de Nantes (UN)-Université de Nantes (UN)
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Mostrar más [+] Menos [-]Inglés. We extended our previous studies based on the design of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents toward the identification of new indol-3-ylmethylamino derivatives. The majority of these compounds exhibited antifungal activity against a Candida albicans strain (minimum inhibitory concentrations ranging from 199.0 to 381.0 ng/mL) suggesting an inhibition of 14α-demethylase by sterol analysis studies, but are weaker inhibitors compared to their indol-5-ylmethylamino analogs.
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