A specific role for <em>PRND</em> in goat fetal Leydig cells is suggested by prion family gene expression during gonad development in goats and mice
2016
Allais-Bonnet, Aurélie | Castille, Johan, J. | Pannetier, Maëlle | Passet, Bruno, B. | Elzaiat, Maeva | André, Marjolaine | Montazer-Torbati, Fatemeh | Moazami-Goudarzi, Katayoun | Vilotte, Jean-Luc | Pailhoux, Eric | Biologie du Développement et Reproduction (BDR) ; École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA) | Allice | Génétique Animale et Biologie Intégrative (GABI) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech
International audience
Mostrar más [+] Menos [-]Inglés. Three genes of the prion protein gene family are expressed in gonads. Comparative analyses of their expression patterns in mice and goats revealed constant expression of <em>PRNP</em> and <em>SPRN</em> in both species and in both male and female gonads, but with a weaker expression of <em>SPRN</em>. By contrast, expression of <em>PRND</em> was found to be sex-dimorphic, in agreement with its role in spermatogenesis. More importantly, our study revealed that <em>PRND</em> seems to be a key marker of foetal Leydig cells specifically in goats, suggesting a yet unknown role for its encoded protein Doppel during gonadal differentiation in nonrodent mammals.
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