The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC–MS/MS analysis
2017
Bonneau, Natacha | Baloul, Lamia | Bajin Ba Ndob, Idensi | Senejoux, François | Champy, Pierre | Institut de Médecine Traditionnelle Chinoise (IMTC) | Unité de Nutrition Humaine (UNH) ; Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]) | Biomolécules : Conception, Isolement, Synthèse (BioCIS) ; Institut de Chimie - CNRS Chimie (INC-CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY) | Centre National de la Recherche Scientifique (CNRS)
The authors are grateful to Dr David Touboul, Isabelle-Schmitz-Afonso (ICSN-CNRS), Dr Marie Mejean and Marine Leblanc for fruitful discussions and guidance, and to Estella Vallade for technical assistance. Natacha Bonneau is the recipient of a doctoral grant from the Ministere de l'enseignement superieur et de la recherche (France)
Mostrar más [+] Menos [-]Inglés. Annonaceous acetogenins (AAGs) are neurotoxins possibly responsible for atypical Parkinsonism/dementiaclusters, via the consumption of edible Annonaceae fruits. Their presence was investigated in fruitpulps of Annona squamosa from different locations. Qualitative analysis of other AAGs was performed.We here report the identification of squamocin in batches from Asia, the Caribbean Basin and theIndian Ocean. This molecule was quantified by HPLC-UV, evidencing a content of 13.5–36.4 mg/fruit.HPLC-ESI-Q-TOF allowed the detection of 25 different raw formulas matching with AAGs. LC–MS/MSmethodological development was performed using 4 representative standards. The main AAGs couldbe annotated, including bullatacin (rolliniastatin-2) and annonacin. This study evidences a remarkablehomogeneity for the main AAGs within the species, and discrepancies for minor compounds. These findingsindicate that A. squamosa should be considered a risk factor for neurodegenerative disorders
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