Stereoselective conversion of sugar derivatives into C-nucleosides
2012
Miguélez, Javier | Batchu, Venkateswara Rao | Boto, Alicia | Ministerio de Ciencia e Innovación (España) | European Commission
A two-step process for the transformation of readily available carbohydrate derivatives into acyclic C-nucleosides is described. The carbohydrate undergoes a scission process that is followed by the addition of aryl ketone derivatives, allowing the introduction of a variety of aryl rings. The resulting acyclic C-nucleosides are transformed into 2-deoxy cyclic pyranosides in good yield and excellent stereoselectivity.
Mostrar más [+] Menos [-]This work was supported by the Research Program CTQ2009-07109 of the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica, Ministerio de Ciencia e Innovación (currently Economı́a y Competitividad), Spain. We also acknowledge financial support from FEDER funds (European Funds for Regional Development).
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