The biogenic amines putrescine and cadaverine show in vitro cytotoxicity at concentrations that can be found in foods
2019
Río Lagar, Beatriz del | Redruello, Begoña | Linares, Daniel M. | Ladero Losada, Víctor Manuel | Ruas-Madiedo, Patricia | Fernández García, María | Martín, M. Cruz | Álvarez González, Miguel Ángel | Ministerio de Economía y Competitividad (España) | Río Lagar, Beatriz del [0000-0001-8107-1975] | Ladero Losada, Víctor Manuel [0000-0002-7613-3745] | Ruas-Madiedo, Patricia [0000-0001-6158-9320] | Martín, M. Cruz [0000-0003-1975-6775] | Álvarez González, Miguel Ángel [0000-0001-9607-7480]
Putrescine and cadaverine are among the most common biogenic amines (BA) in foods, but it is advisable that their accumulation be avoided. Present knowledge about their toxicity is, however, limited; further research is needed if qualitative and quantitative risk assessments for foods are to be conducted. The present work describes a real-time analysis of the cytotoxicity of putrescine and cadaverine on intestinal cell cultures. Both BA were cytotoxic at concentrations found in BA-rich foods, although the cytotoxicity threshold for cadaverine was twice that of putrescine. Their mode of cytotoxic action was similar, with both BA causing cell necrosis; they did not induce apoptosis. The present results may help in establishing legal limits for both putrescine and cadaverine in food
Mostrar más [+] Menos [-]This work was funded by the Spanish Ministry of Economy and Competitiveness (AGL2016-78708-R and AGL2015-64901-R)
Mostrar más [+] Menos [-]Peer reviewed
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