Effect of Saccharomyces cerevisiae boulardii CNCM I-1079 on bile acid signalling in post-weaning piglets

Resumen del póster presentado al 15th International symposium on digestive physiology of pigs (DPP), celebrado en Rotterdam (The Netherlands) del 17 al 20 de mayo de 2022.

This study examined the hypothesis that feeding live yeast Saccharomyces cerevisiae boulardii CNCM I-1079 (LSB) to weanling piglets improves growth performance partially by altering microbial bile acids (BA) metabolism and signaling. To this end, 60 piglets were weaned at 28 days of age and fed either control or LSB-treated diets containing LSB at 2 × 109 colony forming units (CFU)/kg of feed until day 15 postweaning and 1 × 109 CFU/kg until the end of the study on day 36. Piglets were individually weighted at weaning and at days 2, 6, 15, and 36 postweaning. The BA-induced enterokine fibroblast growth factor 19 (FGF19) and BA were measured in samples obtained on days 3 (blood), 6 (feces) and 36 (blood and feces). Before data analysis, piglets were categorized as either high or low performers within treatment based on growth from day 2 to 6. Data were analyzed as repeated measures (sampling day) in SPSS Statistics 26 (IBM) using a mixed model including animal as random effect, and treatment, performance, and their interaction as fixed effects. Feeding LSB to high performers improved body weight and growth on day 15 (P<0.05) and either tended to reduce plasma FGF19 on day 3 (P<0.11) or reduced it on day 36 (P<0.05). These effects were paralleled by a significant treatment x performance interaction (P<0.05) for the fecal and blood content of most BA. Most important alterations were observed at the onset of the study (day 3 and 6), when high performers fed LSB excreted feces with higher (P<0.05) contents of total, unconjugated, and microbiota produced secondary BA, and experienced increased (P<0.05) circulating levels of some of them (hyodeoxycholic and lithocholic acids). Data suggest that animals with high growth potential have a rapid start of BA metabolism in the gut, and that LSB stimulates such an event.

Peer reviewed