Towards an integrated molecular model of plant-virus interactions
2012
Elena, Santiago F.
The application in recent years of network theory methods to the study of host-virus interactions is providing a new perspective to the way viruses manipulate the host to promote their own replication. An integrated molecular model of such pathosystems require three detailed maps describing, firstly, the interactions between viral elements, secondly, the interactions between host elements, and thirdly, the cross-interactions between viral and host elements. Here, we compile available information for Potyvirus infecting Arabidopsis thaliana. With an integrated model, it is possible to analyze the mode of virus action and how the perturbation of the virus targets propagates along the network. These studies suggest that viral pathogenicity results not only from the alteration of individual elements but it is a systemic property.
Mostrar más [+] Menos [-]Spanish Ministry of Science and Innovation BFU2009-06993 EMBO long-term fellowship Marie Curie actions ALTF-1177-2011
Mostrar más [+] Menos [-]Peer reviewed
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Instituto de Biología Molecular y Celular de Plantas