Identification of an avian group A rotavirus containing a novel VP4 gene of close relationship to those of mammalian rotaviruses
2013
Trojnar, E. | Sachsenröder, J. | Twardziok, S. | Reetz, J. | Otto, Peter | Johne, R.
Group A rotaviruses (RVAs) are an important cause of diarrhoeal illness in humans as well as in mammalian and avian animal species. Previous sequence analyses indicated that avian RVAs are only distantly related to mammalian RVAs. Here, the complete genomes of RVA strain 03V0002E10 from turkey (Meleagris gallopavo) and RVA strain 10V0112H5 from pheasant (Phasianus colchicus) were analyzed using a combination of 454 deep sequencing and Sanger sequencing technologies. An adenine-rich insertion similar to that found in the chicken RVA strain 02V0002G3, but considerably shorter, was found in the 3'-noncoding region of the NSP1-gene of the pheasant strain. Most of the genome segments of both strains were closely related to avian RVAs. The novel genotype N10 was assigned to the NSP2 gene of the pheasant RVA, which is most closely related to genotype N6 found in avian RVAs. However, this virus contains a VP4 gene of the novel genotype P[37], which is most closely related to RVAs from pigs, dogs, and humans. This strain may either represent an avian/mammalian rotavirus reassortant or it carries an unusual avian rotavirus VP4 gene, thereby broadening the potential of genetic and antigenic variability among RVAs
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Editorial Microbiology Society (früher: Society for General Microbiology (SGM))
ISSN 0022-1317 | 1465-2099Este registro bibliográfico ha sido proporcionado por German Federal Institute for Risk Assessment