Hospital and community surveys reveal the severe public health problem and socio-economic impact of human echinococcosis in Ningxia Hui Autonomous Region, China.
2006
Yang, Y. R. | Williams, G. M. | Craig, P. S. | Sun, T. | Yang, S. K. | Cheng, L. | Vuitton, D. A. | Giraudoux, P. | Li, Xiaojian | Hu, S. | Liu, X. | Pan, X. | Mcmanus, D. P. | Ningxia Medical College ; Ningxia Medical College | Biomedical Sciences Research Institute ; University of Salford | WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, SERF Unit ; Université de Franche-Comté (UFC) ; Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC) | Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO) ; Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC) ; Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC) | Laboratoire Chrono-environnement (UMR 6249) (LCE) ; Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC) ; Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC) | Brain imaging (LIAMA) ; Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées (LIAMA) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Chinese Academy of Sciences [Changchun Branch] (CAS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institute of Automation - Chinese Academy of Sciences-Centre National de la Recherche Scientifique (CNRS)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Chinese Academy of Sciences [Changchun Branch] (CAS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institute of Automation - Chinese Academy of Sciences-Centre National de la Recherche Scientifique (CNRS) | Molecular Parasitology ; Queensland Institute of Medical Research-The University of Queensland (UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations])-Australian Centre for International and Tropical Health and Nutrition (ACITH)
International audience
Mostrar más [+] Menos [-]Inglés. A comprehensive study of human echinococcosis (caused by Echinococcus granulosus or E. multilocularis), including assessment of hospital records, community surveys and patient follow-up, was conducted in Ningxia Hui Autonomous Region (NHAR), China. In contrast to hospital records that showed 96% of echinococcosis cases were caused by cystic echinococcosis (CE), 56% of cases detected in active community surveys were caused by alveolar echinococcosis (AE). The AE and CE cases co-existed frequently in the same village, even occurring in the same patient. A serious public health problem caused by echinococcosis was evident in southern NHAR, typified by: a long diagnostic history for both AE and CE (7.5 years) compared with a shorter treatment history (4.7 years); a significant mortality rate (39%) caused by AE in one surveyed village, where patients had no previous access to treatment; family aggregation of CE and AE cases; a high proportion of both AE (62.5%) and CE (58%) in females; a high rate of recurrent surgery (30%) for CE demonstrated by surgical records; and frequent symptomatic recurrences (51%) because of discontinuous or sporadic access to chemotherapy for AE. The disease burden for both human AE and CE is thus very severe among these rural communities in NHAR, and this study provides the first attempt to determine the costs of morbidity and surgical intervention of human CE and AE cases both at the hospital and community level in this setting. This information may be useful for assessing the cost effectiveness of designing effective public health programs to control echinococcosis in this and other endemic areas in China and elsewhere.
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