Evaluation of of the performance of the zebrafish (Danio rerio) model in nanotoxicology studies with emphasis on embryo pathology
2021
Ali Reza Radkhah | Soheil Eagderi
The present study was conducted to evaluate the performance of zebrafish (Danio rerio) as a model in embryo and fetal pathology in nanotoxicology studies. Examination of the sources showed that it is possible to completely inhibit hatching and fetal death when exposed to nanoparticles, because nanoparticles interact with hatching enzymes. Zebrafish embryo developmental abnormalities have been studied by several researchers, and incomplete growth and deformity of organs have often been reported. It has also been shown that nanoparticles cause death, delayed hatching and deformation, and growth retardation. However, some researchers in some cases, such as the assessment of skeletal abnormalities, do not consider the use of ZFET as an appropriate model in the early stages of fish life. In general, the use of the ZFET model makes it possible to study the effects of more nanomaterials, and in addition, this model can well show the mechanisms of growth toxicity. Therefore, this model can be used as a suitable approach to evaluate the effects of nanomaterials.
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