First environmental survey of Scedosporium species in Lebanon
2025
Mina, Sara | Yaakoub, Hajar | Razafimandimby, Bienvenue | Dwars, Elske | Wéry, Méline | Papon, Nicolas | Meyer, Wieland | Bouchara, Jean-Philippe | Beirut Arab University [Beyrouth, Liban] (BAU) | Physiopathologie des Adaptations Nutritionnelles (PhAN) ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE) ; Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ) | Infections Respiratoires Fongiques (IRF) ; Université d'Angers (UA)-Université de Brest (UBO) | SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT) ; Université d'Angers (UA) | Westerdijk Fungal Biodiversity Institute [Utrecht] (WI) ; Royal Netherlands Academy of Arts and Sciences (KNAW) | Université d'Angers (UA) | Laboratoire de Parasitologie-Mycologie, CHU d'Angers, Angers,
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Mostrar más [+] Menos [-]Inglés. Background Scedosporium species are filamentous fungi causing a wide spectrum of infections in healthy and debilitated individuals. Despite their clinical significance, the ecology of Scedosporium species remains understudied, particularly in the Middle East. Methods In this context, we conducted an environmental study to elucidate the distribution and ecological preferences of Scedosporium species in the North of Lebanon. One hundred and fifty-five soil samples were collected from different environmental areas and analyzed for several chemical parameters. Scedosporium isolates were then selected for species identification and genotyping. Results Overall, 39 (25.16%) were positive for Scedosporium species, with a predominance of S. apiospermum (80.56%). Soil analysis revealed associations between the fungal presence and pH, nitrogen, phosphorus, and organic matter content. Moreover, genotyping analysis using MultiLocus Sequence Typing identified five major clusters. Interestingly, a number of Lebanese isolates formed an Asian-specific cluster (V) with one clinical Chinese isolate, whereas two clusters (II and III) showed a close association with German isolates, and clusters (I and IV) contained isolates with a global distribution. Conclusion These findings provide new insights into the ecology of Scedosporium species, bridging a gap in our knowledge of their distribution on the Asian continent and laying the groundwork for future clinical investigations. Future international collaborations are essential to trace the origin of S. apiospermum .
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