Evolution of anti-eCG antibodies in response to eCG doses and number of injections. Relationship with productivity of rabbit does | Cinétique de la production d'anticorps anti-eCG en fonction de la dose et du nombre d'injections d'eCG. Relation avec la productivité des lapines
2008
Theau Clément, Michèle | Lebas, François | Beckers, J.F. | Drion, P.V. | Station d'Amélioration Génétique des Animaux (SAGA) ; Institut National de la Recherche Agronomique (INRA) | Association Cuniculture | Faculté de Médecine Vétérinaire, Physiologie de la Reproduction ; Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich (ULiège)
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Mostrar más [+] Menos [-]Inglés. The aim of this experiment was to study the kinetics of anti-eCG (equine chorionic gonadotrophin) antibodies in relation to eCG dose (8 or 25 IU) and number of injections (n511) in comparison with a control group (no injection), and to relate antibody production to sexual receptivity and productivity of rabbit does. In all, 124 lactating primiparous rabbit does were inseminated every 35 days for a year. Just before eCG injection (48 h before insemination), blood samples were collected from all the does to assay anti-eCG antibodies. The anti-eCG antibody binding rate, regardless of the injected dose, shows that none of the does developed detectable anti-eCG antibodies before the 7th injection. The level of detectable anti-eCG antibodies began to show an increase at the 7th injection and was significant only for the 25 IU dose at the 11th injection. At the end of the experiment, 15% and 39% of does treated with 8 and 25 IU, respectively, developed immunity to eCG (binding rate .6%: higher binding rate of the control group). Consequently, the immune response depends on the eCG dose and on the number of injections. Moreover, productivity of does estimated from the number of weaned rabbits produced per insemination is not influenced by the level of eCG antibodies (7.0 and 6.9 for binding rate ,6% and binding rate >6%, respectively). Only 19 inseminations (n56 and n513 for 8 and 25 IU, respectively) were made on hyperimmune does. Consequently, the immune response to eCG seems to be marginal for rabbit does. Moreover, under the described experimental conditions, reproductive performances of hyperimmune does were not affected.
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