Biological activity of copaiba in damage to the alveolar bone in a model of periodontitis induced in rats.
2022
SANTOS, V. R. N. DOS | MOTTA, J. V. DA S. | FRAZÃO, D. R. | FERREIRA, R. DE O. | SOUZA-MONTEIRO, D. | BAIA-DA-SILVA, D. C. | MENDES, P. F. S. | BITTENCOURT, L. O. | MOURA, J. D. M. DE | LAMEIRA, O. A. | BALBINOT, G. DE S. | COLLARES, F. M. | RÖSING, C. K. | LIMA, R. R. | VINICIUS RUAN NEVES DOS SANTOS, UNIVERSIDADE FEDERAL DO PARÁ; JOÃO VICTOR DA SILVA MOTTA, UNIVERSIDADE FEDERAL DO PARÁ; DEBORAH RIBEIRO FRAZÃO, UNIVERSIDADE FEDERAL DO PARÁ; RAILSON DE OLIVEIRA FERREIRA, UNIVERSIDADE FEDERAL DO PARÁ; DEIWESON SOUZA-MONTEIRO, UNIVERSIDADE FEDERAL DO PARÁ; DAIANE CLAYDES BAIA-DA-SILVA, UNIVERSIDADE FEDERAL DO PARÁ; PAULO FERNANDO SANTOS MENDES, UNIVERSIDADE FEDERAL DO PARÁ; LEONARDO OLIVEIRA BITTENCOURT, UNIVERSIDADE FEDERAL DO PARÁ; JOÃO DANIEL MENDONÇA DE MOURA, UNIVERSIDADE FEDERAL DO PARÁ; OSMAR ALVES LAMEIRA, CPATU; GABRIELA DE SOUZA BALBINOT, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; FABRÍCIO MEZZOMO COLLARES, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; CASSIANO KUCHENBECKER RÖSING, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; RAFAEL RODRIGUES LIMA, UNIVERSIDADE FEDERAL DO PARÁ.
Several studies have investigated the effects of natural products in the treatment of diseases. Traditional Amazonian populations commonly use copaiba due to its well-known anti-inflammatory, antibacterial, and healing properties. In this study, we aimed to investigate the effects of systemic administration of copaiba oleoresin (Copaifera reticulata Ducke) on ligature-induced periodontitis in rats. To do so, 21 adult rats were divided into three groups (n = 7 each): a control group, ligature-induced periodontitis group, and ligature-induced periodontitis group treated with copaiba oleoresin (200 mg/kg/day). The ligature remained from day 0 to 14, and the copaiba oleoresin was administered via oral gavage during the last seven days. On day 14, the animals were euthanized, and mandibles were collected for histopathological evaluation and microcomputed tomography analysis. Our data showed that the administration of copaiba considerably reduced the inflammatory profile. Moreover, copaiba oleoresin limited alveolar bone loss, increased trabecular thickness and bone-to-tissue volume ratio, and decreased the number of trabeculae compared with those of the untreated experimental periodontitis group. Our findings provide pioneering evidence that supports the potential of copaiba oleoresin in reducing periodontitis-induced alveolar bone damage in rats.
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