Lung cancer: Animal model of lung cancer, molecular carcinogenesis of lung cancer, and antitumor effect of Ocimum sanctum against lung cancer
2025
Ulayatul Kustiati | Dwi Aris Agung Nugrahaningsih | Dwi Liliek Kusindarta | Hevi Wihadmadyatami
Lung cancer is the leading cause of fatalities related to cancer globally. There are numerous ways to treat lung cancer, including surgery, chemotherapy, and radiation. Since these treatments haven't yet shown satisfactory results, more research into the underlying mechanisms and different approaches to therapy and prevention are needed. Animal models are essential to the study of lung cancer because they offer priceless information about the etiology, course, and possible treatments for the illness. The therapeutic application of phytochemicals and medicinal plants to treat cancer-related compounds has gained attention subsequently. In addition to discussing the molecular carcinogenic and anti-tumor effects of the herbal treatment Ocimum sanctum in connection to lung cancer, this review will address the current awareness regarding lung cancer in animal models. The multitude of animal models utilized in lung cancer research—such as genetically modified mice, carcinogen-induced models, and xenograft induction—provides a solid foundation for understanding the illness. By easing the examination of the environmental and genetic factors involved and enhancing the analysis of possibilities for treatment, these models eventually assist in the further development of lung cancer therapy. Additionally, using the herb plant Ocimum sanctum is essential for both treating and preventing lung cancer. Standardizing dosages and enforcing laws on the use of herbal medications require more in-depth investigation. [Open Vet J 2025; 15(2.000): 482-503]
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