AMELIORATIVE EFFECT OF MELATONIN, VIT.C ALONE AND THEIR COMBINATION ON LIVER AND KIDNEY FUNCTIONS IN ACRYLAMIDE INTOXICATEDOF ADULT MALE RATS
2016
Nawras A. Alwan | Jassim M. A. Alkalby | Eman Aboud Al-Masoudi
The present study was designed to determine the ameliorative effect of melatonin (Mel),vitamin C (Vit.C) alone and their combination on liver and kidney functions in acrylamide (ACR)intoxicated rats(administration ACR for 45days). Forty eight adult male rats were divided randomlyinto two main groups. Control group (no=20) subdivided into two groups: groupI: ten animals ofcontrol administration distal water and group II:ten animals give Mel(5mg/kgBW) for 21 days.second group: the ACR treated group(n=40) subdivided into ACR+distal water orally, ACR+Mel(5mg/kg BW/day), ACR+Vit.C (200 mg/kg BW/day), ACR+Mel (5mg)+Vit.C (200 mg)/kg BW/dayfor 21 days. The result revealed that no significant differences in serum AST, ALT and ALPenzymes levels between control group treated with Mel and control group. A significant reduction inserum AST, ALT and ALP levels were recorded in all treated groups compared with ACR-nontreated group in which the above cited parameters still significantly higher compared with control.No significant differences were recorded in serum total protein, urea and creatinine concentrationsbetween control+Mel treated group compared with control. A significant improvement in serum totalprotein, urea and creatinine concentrations were recorded in all treated groups compared with ACRnontreated group.
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