DETERMINATION OF LD50 AND ACUTE TOXICITY EFFECTS ON SOME BIOCHEMICAL PARAMETERS INDUCED BY AMITRAZ IN RATS
2022
Mahmood B. Mahmood | Zainab T. Mohammed
The aim of the study is determine the toxic effects and some biochemical changesof amitraz insecticide in adult albino female rats. First the median lethal dose ( )of oral amitraz was (717.125mg/kg)and were clear toxic signs of amitraz intoxicationsuch as incoordination, dull, depression, salivation, bulging of eyes, recumbence anddeath. Then alpha 2 (α-2) adrenoceptor antagonist atipamezole at (0.5 and 1mg/kg),and alkalinizing agents sodium bicarbonate at (50 and 100 mg/kg) were given by IProute, 15minutes before giving the oral administration of amitraz improved theprophylactic rates to 14.66 % and 24.45% for atepamizole, and to1.79 % and 17.38%for Sodium bicarbonate respectively, and the toxic signs of amitraz intoxication werereduced when atipamezole and sodium bicarbonate injected. After three hours of oralnon-lethal amitraz dosing with (250 and 500mg/kg) increased serum glucoseconcentration (291.33±2.9 and 328.02±4.8mg/dL) respectively compared with thecontrol group value (134.05±9.6 mg/dL), also the Amitraz at same doses were risenup the level of serum cortisol to (7.30±0.3 and 7.43±0.3 µg/dL) respectively ascompared with the control value (2.39±0.26 µg/dL). Also it causes an increasedserum level of transaminases enzymes (AST and ALT) compared with the controlvalue, while amitraz at (500mg/kg, orally) increased enzyme ALP activity in theserum of rats when it is compared with control value. The results of this study referto that amitraz may cause tissues damage and toxic effects in rats.
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