Suspect and non-targeted screening methodologies for the detection of newly discovered organochlorines: application to chlordecone in food
2025
Martin, Déborah, E | Leblanc, Jean-Charles | Parinet, Julien | Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Food and Agriculture Organization of the United Nations [France] (FAO) ; Food and Agriculture Organization of the United Nations [Rome, Italie] (FAO) | Institut National de la Recherche Agronomique (INRA) | Institut National Agronomique Paris Grignon (INAPG) | ANR-19-CE21-0002,AlimOmic,Traquer les Pesticides Présents dans l'Alimentation par l'Emploi de la Spectrométrie de Masse Haute Résolution : approche ciblée et non-ciblée(2019)
International audience
Mostrar más [+] Menos [-]Inglés. <div><p>A suspect and a non-targeted screening methodologies for new and newly discovered organochlorines not included in databases have been developed. To do this, a mass spectrum library has been created from the literature, along with a study of the various peak picking, deconvolution and annotation parameters. These approaches were then applied to the case of chlordecone and its chemically and structurally various metabolites. Although most of them were recently discovered and are currently present in the environment, only chlordecone and chlordecol, its metabolite, are monitored, which does not reflect the actual exposure of the population. Thanks to GC-HRMS, we focused on suspect screening from a list of 26 organochlorines linked to chlordecone, and non-targeted approaches.</p><p>Applied to chicken, egg, spiny lobster and crayfish samples, several organochlorines linked to chlordecone have been annotated, revealing the diversity of compounds populations are exposed to, and the potential of HRMS to reveal unexpected contamination.</p></div>
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