Emergence and spread of Mycobacterium ulcerans at different geographic scales
2024
Briand, Martial | Boccarossa, Alexandra | Rieux, Adrien | Jacques, Marie Agnès | Ganlanon, Line | Johnson, Christian | Eveillard, Matthieu | Marsollier, Laurent | Marion, Estelle
The classical lineage of Mycobacterium ulcerans is the most prevalent clonal group associated with Buruli ulcer in humans. Its reservoir is strongly associated with the environment. We analyzed together 1,045 isolates collected from 13 countries on two continents to define the evolutionary history and population dynamics of this lineage. We confirm that this lineage spread over 7,000 years from Australia to Africa with the emergence of outbreaks in distinct waves in the 18th and 19th centuries. In sharp contrast with its global spread over the last century, transmission chains are now mostly local, with little or no dissemination between endemic areas. This study provides new insights into the phylogeography and population dynamics of M. ulcerans, highlighting the importance of comparative genomic analyses to improve our understanding of pathogen transmission.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Centre de coopération internationale en recherche agronomique pour le développement