The Comparative Immunotropic Activity of Carrageenan, Chitosan and Their Complexes
2020
Viktoriya N. Davydova | Irina V. Sorokina | Aleksandra V. Volod’ko | Ekaterina V. Sokolova | Marina S. Borisova | Irina M. Yermak
The immunotropic activity of polyelectrolyte complexes (PEC) of &kappa:-carrageenan (&kappa:-CGN) and chitosan (CH) of various compositions was assessed in comparison with the initial polysaccharides in comparable doses. For this, two soluble forms of PEC, with an excess of CH (CH:CGN mass ratios of 10:1) and with an excess of CGN (CH: CGN mass ratios of 1:10) were prepared. The ability of PEC to scavenge NO depended on the content of the &kappa:-CGN in the PEC. The ability of the PEC to induce the synthesis of pro-inflammatory (tumor necrosis factor-&alpha: (TNF-&alpha:)) and anti-inflammatory (interleukine-10 (IL-10)) cytokines in peripheral blood mononuclear cell was determined by the activity of the initial &kappa:-CGN, regardless of their composition. The anti-inflammatory activity of PEC and the initial compounds was studied using test of histamine-, concanavalin A-, and sheep erythrocyte immunization-induced inflammation in mice. The highest activity of PEC, as well as the initial polysaccharides &kappa:-CGN and CH, was observed in a histamine-induced exudative inflammation, directly related to the activation of phagocytic cells, i.e., macrophages and neutrophils.
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