Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives
2009
Amedeo Pau | Gabriele Murineddu | Battistina Asproni | Caterina Murruzzu | Giuseppe E. Grella | Gérard A. Pinna | Maria M. Curzu | Irene Marchesi | Luigi Bagella
Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
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