Brucella-driven host N-glycome remodeling controls infection
2024
Cabello, Ana-Lucia | Wells, Kelsey | Peng, Wenjing | Feng, Hui-Qiang | Wang, Junyao | Meyer, Damien | Noroy, Christophe | Zhao, En-Shuang | Zhang, Hao | Li, Xueqing | Chang, Haowu | Gomez, Gabriel | Mao, Yuxin | Patrick, Kristin L. | Watson, Robert O. | Russell, William K. | Yu, Aiying | Zhong, Jieqiang | Guo, Fengguang | Li, Mingqian | Zhou, Mingyuan | Qian, Xiaoning | Kobayashi, Koichi S. | Song, Jianxun | Panthee, Suresh | Mechref, Yehia | Ficht, Thomas A. | Qin, Qing-Ming | de Figueiredo, Paul | Texas A&M University [College Station] (TAMU) | University of Missouri [Columbia] (Mizzou) ; University of Missouri System | Texas Tech University | Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Jilin University | Cornell University [Ithaca] (CU) | The University of Texas Medical Branch (UTMB) | University of Texas | Texas A&M University Health Science Center;Texas A&M Health;USA;http://dx.doi.org/10.13039/100023887 | Defense Advanced Research Projects Agency;ARPA;USA;http://dx.doi.org/10.13039/100000185 | National Institutes of Health;NIH;USA;http://dx.doi.org/10.13039/100000002 | National Science Foundation;NSF;USA;http://dx.doi.org/10.13039/100000001 | Bill and Melinda Gates Foundation;GF;USA;http://dx.doi.org/10.13039/100000865 | University of Missouri;MU;USA;http://dx.doi.org/10.13039/100007165
Source Agritrop Cirad (https://agritrop.cirad.fr/613155/)
Mostrar más [+] Menos [-]International audience
Mostrar más [+] Menos [-]Inglés. Many powerful methods have been employed to elucidate the global transcriptomic, proteomic, or metabolic responses to pathogen-infected host cells. However, the host glycome responses to bacterial infection remain largely unexplored, and hence, our understanding of the molecular mechanisms by which bacterial pathogens manipulate the host glycome to favor infection remains incomplete. Here, we address this gap by performing a systematic analysis of the host glycome during infection by the bacterial pathogen Brucella spp. that cause brucellosis. We discover, surprisingly, that a Brucella effector protein (EP) Rhg1 induces global reprogramming of the host cell N-glycome by interacting with components of the oligosaccharide transferase complex that controls N-linked protein glycosylation, and Rhg1 regulates Brucella replication and tissue colonization in a mouse model of brucellosis, demonstrating that Brucella exploits the EP Rhg1 to reprogram the host N-glycome and promote bacterial intracellular parasitism, thereby providing a paradigm for bacterial control of host cell infection.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique