Taxus yunnanensis genome offers insights into gymnosperm phylogeny and taxol production
2021
Song, Chi | Fu, Fangfang | Yang, Lulu | Niu, Yan | Tian, Zhaoyang | He, Xiangxiang | Yang, Xiaoming | Chen, Jie | Sun, Wei | Wan, Tao | Zhang, Han | Yang, Yicheng | Xiao, Tian | Dossa, Komivi | Meng, Xiangxiao | Cao, Fuliang | van de Peer, Yves | Wang, Guibin | Chen, Shilin | Chengdu University of Traditional Chinese Medicine (CDUTCM) | Nanjing Forestry University | Shenzhen University [Shenzhen] = 深圳大学 (SZU) | China Academy of China Medical Sciences (CACMS) | Chinese Academy of Sciences [Changchun Branch] (CAS) | Shenzhen University Health Sciences Center | Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro ; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro) | Universiteit Gent = Ghent University = Université de Gand (UGENT)
Source Agritrop Cirad (https://agritrop.cirad.fr/612703/)
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Mostrar más [+] Menos [-]Inglés. Taxol, a natural product derived from Taxus, is one of the most effective natural anticancer drugs and the biosynthetic pathway of Taxol is the basis of heterologous bio-production. Here, we report a high-quality genome assembly and annotation of Taxus yunnanensis based on 10.7 Gb sequences assembled into 12 chromosomes with contig N50 and scaffold N50 of 2.89 Mb and 966.80 Mb, respectively. Phylogenomic analyses show that T. yunnanensis is most closely related to Sequoiadendron giganteum among the sampled taxa, with an estimated divergence time of 133.4−213.0 MYA. As with most gymnosperms, and unlike most angiosperms, there is no evidence of a recent whole-genome duplication in T. yunnanensis. Repetitive sequences, especially long terminal repeat retrotransposons, are prevalent in the T. yunnanensis genome, contributing to its large genome size. We further integrated genomic and transcriptomic data to unveil clusters of genes involved in Taxol synthesis, located on the chromosome 12, while gene families encoding hydroxylase in the Taxol pathway exhibited significant expansion. Our study contributes to the further elucidation of gymnosperm relationships and the Taxol biosynthetic pathway.
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