Effect of consumption of anthocyanin-rich products on NMR lipoprotein subclasses and biomarkers in hypercholesterolemic subjects: a randomized controlled trial (the AppleCOR study)
2025
Pedret, Anna | Llauradó, Elisabet | Calderón-Pérez, Lorena | Companys, Judit | Pla-Pagà, Laura | Salamanca, Patricia | Sandoval-Ramírez, Berner Andrée | Besora-Moreno, Maria | Catalán Santos, Úrsula | Fernández-Castillejo, Sara | Ludwig, Iziar A. | Macià i Puig, Ma Alba | Rubió Piqué, Laura | Sampson, Maureen L. | Remaley, Alan T. | Valls, Rosa M. | Motilva Casado, Mª José | Solà, Rosa
Our aim was to assess the effect of intake of anthocyanin biofortified red-fleshed apples (RFA) versus that of common white apples (WFA) without anthocyanins on the NMR lipoprotein subfraction profile and other NMR metabolites. Additionally, an aronia infusion (AI) arm, matching the anthocyanin content and profile of the RFA, was included. A 6-week, randomized, parallel study was conducted in hypercholesterolemic subjects (n = 121). Anthocyanin-rich products (RFA and AI) decreased LDLc; ApoB; total, large, and small LDL-P; LDL size; TG/HDL ratio; and large TRL, versus WFA. All treatments significantly decreased HDLc, ApoA1, and total HDL-P, with the most significant reductions after RFA treatment. RFA significantly decreased large HDL-P compared to WFA and AI, while medium HDL-P decreased significantly after AI compared to WFA. Anthocyanin-rich products decreased GlycA and alanine and increased acetoacetate versus WFA. WFA and RFA decreased plasma citrate versus AI. Thus, anthocyanin-rich products provided greater protection against CVD risk than WFA.
Mostrar más [+] Menos [-]This Applecor study was funded by Ministerio de Economía, Industria y Competitividad, the Agencia Estatal de Investigación (AEI), and the European Regional Development Fund (ERDF) (grant number: AppleCOR Project, AGL2016- 76943-C2-2-R). The NFOC-Salut group is a consolidated research group of Generalitat de Catalunya, Spain (2014 SGR 873, 2017 SGR 522 and 2021 SGR 817). We also want to thank the Calidad Pascual company, Bezoya (Aranda de Duero, Burgos, Spain) for providing the mineral water necessary for the preparation of the AI.
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