Generation of an induced pluripotent stem cell line SYSUi-004-A from a child of microcephaly with TYW1 mutations
2020
Chuanbo Sun | Pei Zhou | Simin Yuan | Ruirui Guo | Zhan Zhang | Qingyang Xu | Dingding Han | Lu He | Hongmei Tang | Kaishou Xu | Hao Hu | Na Li
We generated an induced human pluripotent stem cell line from a child with microcephaly carrying compound heterozygous mutations of TYW1 inherited from healthy parents. This iPS cell line showed typical embryonic stem cell-like morphology, expressed pluripotent markers that comparable to human embryonic stem cells. Moreover, these cells have the ability to differentiate into three germ layers and maintain a normal karyotype.
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