Evaluation of isometamidium levels in the serum of sheep and goats after prophylactic treatment against trypanosomosis
2004
Wesongah, J.O. | Murilla, G.A. | Kibugu, J.K. | Jones, T.W.
years, but recently there have been reports of prophylaxis failure under natural conditions. In this study, use of the drug for prophylactic purpose against trypanosomosis in small ruminants was investigated. Forty-two sheep and 44 goats were divided into four treatment groups. Groups 1 and 2 were treated with isometamidium chloride (Samorin(R), Rhone Merieux, Lyon, France) at 3-month intervals while groups 3 and 4 were used as controls. All the animals were exposed to natural tsetse challenge and monitored for serum isometamidium levels and anti-trypanosome antibodies. Seven days after drug administration, isometamidium levels were significantly higher in goats 13.7 + 0.07 ng/mℓ than in sheep 6.2 + 0.06 ng/mℓ. However, the elimination half-life in the sheep was 14.2 + 0.92 days and was significantly higher (P 0.05) than that of the goats 12 + 0.5 days. This study established that isometamidium metabolism differs between sheep and goats and this difference may have important implications in high tsetse challenge areas.
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